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Working with solitary-molecule optical and AFM imaging and power-spectroscopy tactics, we seek out to unravel the mechanistic facets of the construction and dynamics of chromosomes. Our exploration pursuits involve:

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Non-equilibrium folding of particular person DNA molecules recaptured nearly a thousand periods in a very stable point out nanopore

That may be a dream of mine and we set to operate with a tasty dose of naivety. This is certainly something which will probably produce amazing results in the more time time period, but that doesn't make any difference. You should not only want to work about the thoughts of tomorrow, but additionally to the thoughts from the day immediately after tomorrow.’

Microbiology has only existed for just a century, because we started to research micro-organisms a lot more significantly. I believed nanobiology was an acceptable expression, since all molecular biological pertinent interactions happen with the nanoscale: a protein is a number of nanometres in dimensions, DNA is two nm thick.’

What distinguishes biology from chemistry is always that these components jointly make up a living technique. The secret of explained life, I feel, lies in the interactions, the interplay of Those people molecules. The large dilemma in regards to the origin of everyday living continues to be unanswered. How did we at any time evolve from easy molecules in to the particularly complicated devices we see today? We don't know. I need to operate on these kinds of massive, open up concerns.’

2011, very first in vitro measurements of transportation across a single biomimetic nuclear pore elaborate; progress of multiplexed magnetic tweezers for kilo-molecule experiments; and settled the system of homology recognition in DNA homologous recombination

The rotors harness Vitality from the nanoscale water and ion stream that's produced by a static chemical or electrochemical potential gradient while in the nanopore, which are proven via a salt gradient or applied voltage, respectively. These synthetic nanoengines self-Manage and work autonomously in physiological disorders, suggesting methods to cees dekker constructing Power-transducing motors at nanoscale interfaces.

It absolutely was throughout this period that Dekker carried out research on magnetic spin systems and on sounds in superconductors and semiconductors.

In 1993 he was appointed as Associate Professor at Delft College of Technologies. From the mid-nineties Dekker and his workforce reached results with the discovery on the Digital Qualities of carbon nanotubes, the 1st one-molecule transistor and also other nanoscience.

1999, first measurement in the wavefunction of solitary molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive proof for a new Luttinger description of interacting electrons in nanotubes

2005, discovery with the mechanism of DNA uncoiling by topoisomerase enzymes; discovery of prolonged-vary conformational adjustments in Mre11/DNA maintenance complexes; and very first drive measurements on a DNA molecule in the nanopore

The biophysicist from Delft – who has actually been Among the most cited researchers within the Netherlands For a long time – normally takes his duty to contribute into the rationalization and popularisation of his operate on the border of physics and biology very seriously and consistently seems within the media; Otherwise to mention his perform, then about the relationship involving science and his Christian faith.